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Re: PKD and exercise
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Gayle C Willman
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Nov 05, 2009 07:18 PST
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Re: running - when you exercise, your muscles generate toxins... it's
what makes muscles sore, and it makes your blood somewhat acidic. If
you have poor kidney function, I suppose your body would have a hard
time cleaning out the toxins - but everything I've read about exercise
says there's a "net gain" - exercise increases your body temperature,
which expands capillaries, which - in turn - makes it easier for your
body to clean up any waste products that need to go.
On Thu, Nov 5, 2009 at 9:07 AM, Anamarija Richter
<anamarija-@gmail.com> wrote:
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I did not think one could drink too much water, but a doctor I saw in 200=
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5, before I had seen the one in 2007, saw my 24-hour urine output=C2=A0 and=
said I was "overloading" the kidneys and advised me not to drink this much=
. I had even attempted to follow this order, but I was always feeling someh=
ow weak and generally unwell, which I think was due to dehydration. I do no=
t think that I drank less than 2.5 - 3 L a day though, but I think I am use=
d to more. This new doctor (the one who advised against running) was not sa=
ying anything about "overloading" the kidneys so I increased the water inta=
ke again and have felt much better since. However, I am still not sure if h=
e is right about running.
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On Thu, Nov 5, 2009 at 3:02 PM, Gayle C Willman <gcwil-@gmail.com> wro=
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te:
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I don't think you can drink "too much" water - if you check with Diane o=
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r the PKDiet web site, I think you'll find some info about a study re: drin=
king LOTS of water - it's actually good for PKD.
| | | | Based on my experience, anything that increases circulation seems to mak=
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e my kidneys feel better.
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On Thu, Nov 5, 2009 at 8:50 AM, Anamarija Richter <anamarija.richter@gma=
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il.com> wrote:
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Thanks for the answer.
The water is not a problem, I have always drunk a lot of water, and hav=
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e often been told by people I drank "too much."
| | | | | | Yes, I forgot to mention that this doctor had recommended to me to lie =
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down for at least an hour during day, which I cannot really do, as I work r=
ather far from home. I had an impression that he generally advised against =
running as being "bad for kidneys," not necessarily only because of rupture=
, but because of fear of dehydration and other possible bad influence, but =
I could not really understand what he meant by that.
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On Thu, Nov 5, 2009 at 2:40 PM, Gayle C Willman <gcwil-@gmail.com> w=
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rote:
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My nephrologist advised against certain kinds of "high impact" exercis=
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e, like jogging, because very large cysts can tear or rupture. At the same =
time, he recommended regular strenuous exercise - walking, swimming, etc. I=
bought a Gazelle exercise machine, very low impact but good cardio results=
- haven't had any problems with that or any other low impact exercise.
| | | | | | | | I also take a daily "kidney nap" for about a half hour or so. I find t=
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hat, as the day goes on, gravity comes into play - these short periods of b=
eing horizontal really help a =C2=A0lot!
| | | | | | | | During the course of an average day, I drink at least 3 L of water, of=
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ten more than that. I bought a really good water filter (a Doulton) and kee=
p a glass of water handy all the time - and have one by the bed to drink at=
night.
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On Thu, Nov 5, 2009 at 3:41 AM, Anamarija Richter <anamarija.richter@g=
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mail.com> wrote:
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Dear All,
I was diagnosed with PKD when I was 29 (I am now 36), after about two=
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years of inexplicable pain episodes in my stomach and flanks. For a while =
I had problems that were ascribed to bacteria in the cysts, which caused fr=
equent urinary tract infections, and which discontinued after some speciall=
y targeted medication.
| | | | | | | | | | Two a half years ago, my mother started dyalisis due to PKD and I dec=
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ided to do more regular checks myself, as I was not really taking this cond=
ition seriously at all, and thought it was something that was not so proble=
matic. When I saw a nephrologist, he said that I already have a large numbe=
r of cysts and seemingly my kidneys are slightly enlarged. All my bloodwork=
is still normal, and I had asked him about the possibilities of slowing do=
wn the process of cyst enlargement. He advised me not to eat too much meat,=
which is consistent with what I read in your e-mails, and at various websi=
tes, but he also advised me to avoid strenuous exercise, as it is allegedly=
not good for the kidneys, as they only work properly when we lie down and =
rest.
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I have not been able to find this information anywhere on the Interne=
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t. Though I am aware that Internet may not always be the most reliable sour=
ce, I have not even seen it mentioned anywhere. For some time, I did not do=
running, but just walking and light bicycle riding, but slightly more vigo=
rous exercise is rather important to me in order to keep my weight under co=
ntrol since I quite smoking. By that I do not mean marathon running at all,=
but rather jogging on the treadmill with the occasional minute of fast pac=
e for 30 minutes several times a week. He explained that due to my conditio=
n I am always slightly dehydrated, due to polyuria (another issue that I wa=
s not able to find as the most prominent PKD symptom), caused by the body n=
ot being able to properly "clean" and therefore excreting more liquid. That=
is why there is a risk of dehydrating while doing exercise, due to too muc=
h sweat. He advised to take at least 1 L of water while exercising, and I h=
ave noticed that I am indeed finding the exercise easier if I drink somethi=
ng like 1.5 L during the exercise - this is on top of the daily intake of w=
ater.
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Would anybody have more information on this?
Thank you,
Anamarija
On Thu, Oct 29, 2009 at 7:39 PM, Diane <Dia-@pkdiet.com> wrote:
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Some members have chronic pain from PLD and take opiods which can le=
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ad to constipation. Here is a new drug to ask your docs about if this apply=
s to you.
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ACG: Compound Eases Constipation for Opioid Patients
By=C2=A0Kristina Fiore, Staff Writer, MedPage Today
Published: October 28, 2009
Reviewed=C2=A0by=C2=A0Zalman S. Agus, MD; Emeritus Professor
University of Pennsylvania School of Medicine and
Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner
SAN DIEGO -- An investigational drug increased spontaneous bowel mov=
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ements for patients with opioid-induced constipation, researchers said here=
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Bowel movements per week increased from about one at baseline to fiv=
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e or six, depending on the dose used, Lynn Webster, MD, of Lifetree Clinica=
l Research in Salt Lake City, and colleagues reported at the American Colle=
ge of Gastroenterology meeting here.
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The drug, NKTR-118, "increased the frequency of bowel movements with=
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out a reversal of analgesia, and it was reasonably safe with no serious pro=
blems in this study," Webster said.
| | | | | | | | | | | | He said constipation is a common side effect of opioid therapy, affe=
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cting about 40% to 60% of patients on chronic or acute treatments.
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The investigational compound is a polymer form of naloxone that anta=
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gonizes peripheral opioid receptors in the gut. It can act selectively, pre=
venting it from reversing opioid pain management, the researchers said.
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For their Phase-II, randomized, double-blind, placebo-controlled tri=
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al, the researchers recruited patients on stable regimens of opioids who co=
nsistently had fewer than three spontaneous bowel movements per week.
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A total of 208 patients were randomized to either a 5-mg, 25-mg, or =
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50-mg dose of NKTR-118 or placebo for four weeks.
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The researchers found that spontaneous bowel movements increased sig=
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nificantly for patients on the 25-mg and 50-mg dose compared with placebo.
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Patients on the 25-mg dose increased to five spontaneous bowel movem=
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ents per week, up from 1.4 per week at baseline, whereas placebo patients i=
ncreased to just 3.1 per week from 1.2 at baseline.
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Those on the 50-mg dose had six spontaneous bowel movements per week=
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, up from 1.6 at baseline -- a significant improvement compared with those =
on placebo, who increased to 3.3 per week from 1.4 at baseline.
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Spontaneous bowel movements for patients on the 5-mg dose did not di=
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ffer significantly from those on placebo, the researchers said.
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The median time to first bowel movement was 6.6 hours for those in t=
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he 25-mg dose, compared with 48.6 hours for those on placebo (P=3D0.001). I=
t was 2.9 hours for those on the 50-mg dose, compared with 44.9 hours with =
placebo (P=3D0.002).
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Webster said that there was no change in patient pain, and there wer=
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e no changes in the amount of opioid used for any patient.
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However, dropout rates were significantly higher for the 50-mg dose =
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of the drug compared with placebo, "probably due to the side effect profile=
," Webster said.
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The most significant side effects associated with the drug were gast=
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rointestinal in nature, and included nausea and abdominal pain.
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Side effects were not significantly different for the 5-mg dose comp=
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ared with placebo, and there was more nausea in the placebo group for the 2=
5-mg dose, but side effects were significantly higher in the 50-mg dose com=
pared with placebo.
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There was also one serious adverse event in the 50-mg dose, with a p=
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atient admitted to the hospital for excessive abdominal cramping.
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